Autoantibody testing of a patient with an autoimmune disorder reveals high titers of antibodies against the
core proteins of small nuclear ribonucleoprotein particles (Smith antigen). Based on this finding, detection
of which of the following is the most important initial clinical feature of this autoimmune disorder?
Aspecimen of thick, bloody sputum from a hospitalized 80-year-old patient with chronic obstructive
pulmonary disease is sent for laboratory analyses. The tests yield heavy growth of a lactose-positive,
nonmotile, gram-negative rod with a large gelatinous capsule. Which of the following is this bacterium most
likely to be?
A 14-year-old boy presents with acne with inflamed follicles and sebaceous glands. Gram stain of a pustule
from his face reveals pleomorphic gram-positive bacilli. Which of the following is the organism implicated in
this condition?
A number of children are hospitalized with bloody diarrhea and severe hematological abnormalities. A4-
year-old girl dies of kidney failure shortly after admittance. Epidemiological investigation establishes that all
of the patients developed symptoms soon after consuming hamburgers from the same fast-food restaurant
chain. Which of the following organisms is most likely to be responsible for the outbreak?
Asmall gram-negative pleomorphic organism was isolated from the nasal secretion of a toddler who later
had paroxysms of coughing and post-tussive vomiting lasting at least 2 weeks. Which of the following
culture media should be used to culture the suspected organism?
Mumps virus accounts for 1015% of all cases of aseptic meningitis in the United States. Which of the
following is most true of infection with mumps virus?
A 60-year-old man arrives at the emergency room with chills, high fever, headache, and muscle pain. He is
a slaughterhouse worker. Believing he had a flu, the man had stayed at home for 9 days after the onset of
the symptoms. You suspect a diagnosis of leptospirosis. What body fluid should the clinical laboratory
check for the presence of L. interrogans?